Abstract
The synthesis and the structure activity of a new series of pyrrolo[1,2-a]pyrazine is reported. These molecules are potent and selective non-competitive mGluR5 antagonists and may shed new light on the pattern of substitution tolerated by this receptor.
MeSH terms
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Dopamine Plasma Membrane Transport Proteins / antagonists & inhibitors
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Fluorescence
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Humans
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Molecular Structure
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Norepinephrine Plasma Membrane Transport Proteins / antagonists & inhibitors
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Pyrazines / chemical synthesis
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Pyrazines / pharmacology*
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Pyrroles / chemical synthesis
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Pyrroles / pharmacology*
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Receptor, Metabotropic Glutamate 5
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Receptors, Metabotropic Glutamate / antagonists & inhibitors*
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Structure-Activity Relationship
Substances
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Dopamine Plasma Membrane Transport Proteins
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GRM5 protein, human
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Norepinephrine Plasma Membrane Transport Proteins
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Pyrazines
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Pyrroles
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Receptor, Metabotropic Glutamate 5
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Receptors, Metabotropic Glutamate